[HTML][HTML] Sex differences in brown adipose tissue function: sex hormones, glucocorticoids, and their crosstalk

K Kaikaew, A Grefhorst, JA Visser - Frontiers in endocrinology, 2021 - frontiersin.org
… to this and, therefore, it is important to address the underlying … we discuss the role of sex
hormones in the regulation of BAT … role of estrogens on 11βHSD1. Whether sex hormones also …

[HTML][HTML] Glucocorticoids and Brown Adipose Tissue: Do glucocorticoids really inhibit thermogenesis?

IHN Luijten, B Cannon, J Nedergaard - Molecular Aspects of Medicine, 2019 - Elsevier
… to play an important role in energy homeostasis and adipose tissue … The function of brown
adipose tissue (BAT). Centers in the … where it functions as a transcription factor, regulating the …

Increased central adiposity and decreased subcutaneous adipose tissue 11β‐hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose …

RK Crowley, CP Woods, BA Hughes… - Clinical …, 2019 - Wiley Online Library
… Another important consideration is the role of lean mass in … We have previously shown
that 11β-HSD1 can regulate … ; we have not assessed functional activity in adipose tissue (although …

Prednisone stimulates white adipocyte browning via β3-AR/p38 MAPK/ERK signaling pathway

S Mukherjee, JW Yun - Life sciences, 2022 - Elsevier
roles in the control of fat depots, by regulating adipogenesis … -hydroxysteroid dehydrogenase
type 1 (11β-HSD1), which is … in acutely elevating the brown adipose tissue by upregulation …

Expression and activity of the cortisol-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 is tissue and species-specific

C Dammann, C Stapelfeld, E Maser - Chemico-Biological Interactions, 2019 - Elsevier
… Physiologically, 11β-HSD1 seems to play important roles in the … on global 11β-HSD1
knockout and adipose 11β-HSD1 … In our study, we demonstrated that 11β-HSD1 regulation

The glucocorticoid receptor in brown adipocytes is dispensable for control of energy homeostasis

C Glantschnig, F Mattijssen, ES Vogl, A Ali Khan… - EMBO …, 2019 - embopress.org
… and are of eminent importance in the regulation of metabolic … 11β-HSD1 loss of function
seems curious, as an 11β-HSD1 … an important role of the GR in both white and brown adipose

11β-HSD As a new target in pharmacotherapy of metabolic diseases

D Kupczyk, R Bilski, M Kozakiewicz… - International journal of …, 2022 - mdpi.com
… For the proper functioning of the body, strict control of their … They play an important regulatory
role in the metabolism of … level of 11β-HSD1 expression in adipose tissue and a higher …

Mechanisms in endocrinology: local and systemic effects of glucocorticoids on metabolism: new lessons from animal models

M Swarbrick, H Zhou, M Seibel - European journal of …, 2021 - academic.oup.com
regulate a remarkable variety of essential functions, including … been shown to influence brown
adipose tissue thermogenesis (… of glucocorticoid actions by 11β-HSD1 in this depot and its …

Distinct response of adipocyte progenitors to glucocorticoids determines visceral obesity via the TEAD1‐miR‐27b‐PRDM16 axis

Y Lv, F Xia, J Yu, Y Sheng, Y Jin, Y Li, G Ding - Obesity, 2023 - Wiley Online Library
… -specific pattern, the regulatory pathways of novel progenitor … strongly promoted the brown
adipogenic potential of both … GC activity within adipose tissue by 11β-HSD1, an amplifier …

HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling

M Giroud, FF Tsokanos, G Caratti, S Kotschi, S Khani… - Diabetologia, 2021 - Springer
… (SVF; mSVF) was isolated from brown adipose tissue (BAT), scWAT, and … As adipocyte
function is an important pillar of lipid … an important role very early in the adipocyte differentiation …